Once all the needles have sunk to the bottom and the tea has cooled, pour through a strainer into I didnt die from drinking raw milk either. Descriptions. Before you begin treatment with suramin, you and your doctor should . "Antiproliferative effects of suramin on lymphoid cells." The Journal of clinical investigation 90, no. The Neem's active substance, azadirachtin, 51 a tetranortriterpenoid plant limonoid, is a potent insect feeding deterrent and, if consumed, 52 causes . Journal of cellular biochemistry 29, no. 21. Free shipping. Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. Journal of ethnopharmacology 35, no. 6 (1992): 881-889. Common side effects of suramin include shock, dizziness, fatigue, headache, loss of consciousness, peripheral nerve damage (neuropathy . It is illegal to use suramin in humans for any purpose in the US except in FDA-approved clinical trials. UC San Diego Health, May 26, 2017, "Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy", "Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial", "Q and A - Suramin and Autism | UC San Diego Health", "Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases", https://en.wikipedia.org/w/index.php?title=Suramin&oldid=1126333005, Antrypol, 309 Fourneau, Bayer 205, others, This page was last edited on 8 December 2022, at 20:02. This compound is known to inhibit the binding of growth factors (eg, epidermal growth factor [EGF], platelet-derived growth factor [PDGF], tumor growth factor-beta [TGF-beta]) to their receptors and thus antagonize the ability of these factors to stimulate growth of tumor . Journal of Clinical Oncology 7, no. 2. Suramin was first synthesized by Bayer chemists in Germany in 1916. "Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.). Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor.Suramin efficiently . COVID-19 pandemic. You must log in or register to reply here. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. He knew they would tamper with our food supply, robbing it of all the necessary nutrients for life and health. Jacques Update:Facebook and social media platforms are cracking down on Conservative/holistic health content. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Rooibos Tea has become our all-time favourite tea now. ", 9. Could you please attach links if possible. She was annoyed people were being told to make it. It loves the cold, the colder the better. Dr. Daniels has now been using this and has no issues and I have been using it also. Pure suramin is colorless when dissolved in water or saline as a 10% solution (100 mg/mL). 3 (1985): 265-273. The same protocol is very useful to protect those concerned with the spike protein transmission FROM those whove been injected. Word is spreading that pine needle tea may offer a solution against covid vaccine "shedding" [] [4] It is unclear if it is safe when breastfeeding. (PDF). When given as a medication, it is usually delivered as the sodium sulfonate salt as this formulation is water-soluble, though it does deteriorate rapidly in air. The research is promising and the findings are backed up by similar studies. It is our hope that each success will lay the groundwork for more successes, and soon there will be a drug, device, and therapeutic Renaissance that will create dozens of new tools that doctors can use to regulate the cell danger response and help patients heal. These days I get to enjoy Fennel whenever I so choose, and thats often. But raw milk just doesnt last as long in the fridge, so keep most of it in the freezer and only bring out one serving at a time into the fridge the night before using. 15.Mooon, Jeong-jo, Young-bok Han, and Jin-suk Kim. So because of all this people take their safe and effective jab believing that no-one would do anything to harm them not unless they are a murderer, or maybe a terrorists! I have a 21 year old son with autism Before you begin treatment with this medicine . Thank you so much. [24][25][26][27], 8,8'-{Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}di(1,3,5-naphthalenetrisulfonic acid), O=C(Nc1cc(ccc1C)C(=O)Nc3c2c(cc(cc2c(cc3)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c8cccc(NC(=O)Nc7cc(C(=O)Nc6cc(C(=O)Nc5c4c(cc(cc4c(cc5)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)ccc6C)ccc7)c8, InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80), The references used may be made clearer with a different or consistent style of, World Health Organization's List of Essential Medicines, Learn how and when to remove this template message, "Suramin Injection Advanced Patient Information", "Micromedex Detailed Drug Information for the Consumer: Suramin (Injection route)", "Our Formulary Infectious Diseases Laboratories CDC", "Trypanosomiasis, human African (sleeping sickness)", "CDC Infectious Diseases Laboratory: Our Formulary", "Suramin Injection Advanced Patient Information - Drugs.com", "Synthesis and StructureActivity Relationships of Suramin-Derived P2Y, "Inhibition of receptor/G protein coupling by suramin analogues", "International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy", "International union of pharmacology. Albulescu, I.C., Kovacikova, K., Tas, A., Snijder, E.J., and van Hemert, M.J. (2017). et Zucc. The first thing we noticed was the improvement in his articulation. Eastern White Pine Tree Needles: A Natural Source of Anti-Infective Compounds, Suramin is strongly inhibitory to the replication of the coronavirus spike protein. Many generations of locals strengthen their immunity with the help of natural teas from: Pine tree cones. Turn your volume down inititially. It is considered a ryanodine agent . Just a point of clarification. Suramin is not approved for any use in humans in the United States except to handle the few cases of African sleeping sickness (trypanosomiasis) that have recently traveled from Africa. It's considered almost a pest in New Zealand as it's everywhere. (137) $15.99 New. Re: Pine Needle Tea, Suramin, & Shakimic Acid Date and Time: Monday, May 17, 2021 at 10:55 p.m. Dear Herbal Lover, Word is spreading that pine needle tea may offer a solution against covid vaccine "shedding" or . "Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.)." 9. Too many people have stated its what they used with great results. Jason Shurka was interviewing Dr Judy Mikovits PhD., and he asked the leading question: Do you know of any way, to heal oneself from the injuries from the current injection? Find many great new & used options and get the best deals for PINE NEEDLE TEA 70GM PINUS SILVESTRIS VITAMIN A C ANTIVIRAL ANTIOXIDANT SURAMIN at the best online prices at eBay! 2017-2023 Dr. James Odell, ND, OMD, L.Ac. If you continue to use this site we will assume that you are happy with it. As we know, oil and water do not mix, but this mixes the oil into the water long enough for me to have a drink. 16.Spigelman, Zachary, Amy Dowers, Susan Kennedy, Dennis DiSorbo, Michael O'Brien, Ronald Barr, and Ronald McCaffrey. 20. I'm fascinated and excited by this new research on cell danger response (CDR): Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial abstract and the ramifications for autism as well as anxiety and other chronic health conditions. Create an account to follow your favorite communities and start taking part in conversations. This is a highly concentrated - potent extract that has been created to ensure maximum bioavailability with an easy dosing solution. [3] In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO). 12.Cheng, B., Gao, F., Maissy, E., and Xu, P. (2019). The all natural form of suramin might be licorice root, NAC,vitamin C , green tea. We make no representations, nor any warranties, nor assume any liability for the content herein; nor do we endorse any particular product, provider, or service. 2. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. This is the most important Antidote. Curcumin was the active ingredient in an intravenous infusion that killed the patient of a California-licensed naturopathic doctor. Press question mark to learn the rest of the keyboard shortcuts. Suramin is manmade and is not a natural product found anywhere in Nature. Reddit and its partners use cookies and similar technologies to provide you with a better experience. A polyanionic compound with an unknown mechanism of action. By facilitating the exit from the arrested mitochondrial progression needed to complete the healing cycle, recovery from chronic illnesses currently considered incurable may one day be possible. It is a symmetric molecule in the center of which lies a urea (NHCONH) functional group. Yes, it can certainly be found naturally. Researchers Studying Century-Old Drug in Potential New Approach to Autism. Thank you!). Content may not be reproduced in any form. Myers, Charles, Michael Cooper, Cy Stein, Renato LaRocca, M. M. Walther, Gary Weiss, Peter Choyke, Nancy Dawson, Seth Steinberg, and Margaret M. Uhrich. But, I would research it to the uttermost if I were you! [5] It is on the World Health Organization's List of Essential Medicines. . . I was excited by these findings too esp as I am also on the autism spectrum. Antiviral research 7, no. I always come back to the analogy of a car. But it would be fine to do both. Myers, Charles, Michael Cooper, Cy Stein, Renato LaRocca, M. M. Walther, Gary Weiss, Peter Choyke, Nancy Dawson, Seth Steinberg, and Margaret M. Uhrich. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 M), and SirT5 (IC50=22 M). to protect from transmission from the V and to help those who took the V, We are covering everything from vaccines, parenting topics, alternative medicine, and. "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR2B cells." The chemical structure of suramin was kept secret by Bayer for commercial and strategic reasons, but it was elucidated and published in 1924 by Ernest Fourneau and his team at the Pasteur Institute. Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. "Suramin in the treatment of AIDS: mechanism of action. I think you should take this post down, if someone were to try this remedy and then get worse they kudzu. Xu, H. Eric, Wanchao Yin, Xiaodong Luan, Zhihai Li, Leike Zhang, Ziwei Zhou, Minqi Gao et al. SMALL SURAMIN STUDY. This also can be made up into a tea. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143661/, https://news.ycombinator.com/item?id=14458230. by Kim Molisani January 2, 2022. Hmm, if it does, my father might have been on to something. We are covering everything from vaccines, parenting topics, alternative medicine, and I just gave my testimony of past abortion. In summary, a lowered pHe enhanced the activity of all agonists at P2X2 receptors but, with the exception of suramin, not antagonists. XXIV. Of-course there are others but you do need to do your own research concerning the types of pines in your area. In addition, pharmaceutical grade suramin is hard to make. It is not found in pine needles and cannot be found in any herbal teas. HUGE! They were ahead of their time back then. Published: Jul 27, 2021 By Jacqueline 37 Comments. Studies on this have just recently started . This information isn't meant to treat, cure or prevent any disease. 6. I believe the White Pine is totally safe as well. Any natural medicine with 0.01% of these deaths and side effects would have been pulled from the market immediately . Not landscapers just the people that own their homes. The simplest and most common of weeds are often the very medicine we need to counteract our ill health. The regimen commonly prescribed to treat CNS-stage disease involves the use of the trypanocidal drugs suramin and melarsoprol. "Suramin: an anticancer drug with a unique mechanism of action." cryoEM studies reveal the binding of suramin to the RdRp catalytic site to prevent . They are SO strict with raw over here. Stinging nettle can be found online and at health food stores. If this works, it would literally be an answered prayer ! [23], Suramin has been studied in a mouse model of autism and in a small phase I/II human trial. It would be interesting to know if I can get raw camel milk in Australia at least in the powdered form. Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. Try to put aside your previous teaching and open your spirit to receive from God. Cat's claw, hailing from a woody vine in the Amazon rainforest, is another herb with spectacular antiviral properties. 17 (1987): 4694-4698. Accelerated catch-up development occurs in the first few weeks when the brakes are removed because the child is ready to develop, but was otherwise blocked by their illness. Unfortunately, the lawns that do not have any yellow flowers have often been treated with RoundUp which is about the very worst thing you can do. According to a comment on a doctor video [17]:378379[18], It is also used as a research reagent to inhibit the activation of heterotrimeric G proteins in a variety of GPCRs with varying potency. I wish I could. The drug is still sold by Bayer under the brand name Germanin. My high quality source was, of course, wikipedia, but here are some better ones. i just emailed a well known ME/CFS doctor i know (who wishes to remain anonymous) with the names of the two herbs/supplements mentioned at the top of this thread, and he said: "I have talked with every prominent herbalist I know to see if there is a similar substance out there, and so far, nothing.". I've come across two over the counter supplements that inhibit the same purinergic receptors. Careful clinical trials will be needed over several years at several sites to learn how to use low-dose suramin safely in autism, and to identify drugdrug interactions and rare side effects that cannot currently be predicted. Though it has been investigated for other diseases, including cancer, it is not approved for any therapeutic use in the United States. By the way, enterovirus can cause gastritis, as well as being linked to ME/CFS. (2020). We strongly caution against the unauthorized use of suramin.1Homeopathic use of suramin is also illegal and untested. Suramin is 20 or more times as powerful as remdesivir, which is the only currently approved anti-COVID-19 drug. Journal of clinical oncology 10, no. So I encourage you to play with these things. 2. (2020). UPDATE 8/1: Now graphene oxide has been confirmed with irrefutable documentation by former Pfizer employee whistleblower and current analyst for the pharmaceutical and medical device industrieshere. Check with your physician if you . Cat's Claw. doi: https://doi.org/10.1101/2020.10.06.328336. Find a way that works for you so you can enjoy Suramin often throughout the day. ?? et Zucc." 22. [10] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision. , But I know that people have sprayed round up around their yards on dandelions and thistles. Sent in accordance with our Privacy Policy. For alcohols with a molecular volume of < or = 42.2 ml/mol, potency for inhibiting ATP-activated current was correlated with lipid solubility (order of potency: 1-propanol = trifluoroethanol > monochloroethanol > ethanol > methanol). a cup and enjoy! ", 16.Spigelman, Zachary, Amy Dowers, Susan Kennedy, Dennis DiSorbo, Michael O'Brien, Ronald Barr, and Ronald McCaffrey. 4 (1989): 499-508. Once all the needles have sunk to the bottom and the tea has . All vaccine people die . This has me very excited. The best kind would be to get actual frozen raw camel milk. Cells were cultured in the presence of suramin for either0h(top)or72h (bottom). ", 20. The intracellular application of 100 mM ethanol did not affect the inhibition of current by 100 mM extracellular ethanol, suggesting that the alcohol inhibition of ATP-gated ion channel function involves the extracellular domain of the receptor. It is still early to say but maybe this will enter the top three interventions. Lots of amazing eating benefits in those ones. You must realise too that the medbeds are for good and not evil. Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. Dr. Naviaux no longer has any control over the next clinical studies or the priorities of different diseases for testing, although he is recommending ASD, ME/CFS, post-acute SARS-CoV-2 multi-system chronic fatigue syndrome, also called long-COVID, and post-treatment Lyme disease (PTLDS) as a few of the top candidates. De Clercq, Erik. However. The exceptions to this are the P2Y12 inhibitors like Plavix, which inhibit ADP-stimulated platelet aggregation. [11], The molecular formula of suramin is C51H40N6O23S6. To evaluate the localization of this presumed alcohol binding site, the effect of the intracellular application of ethanol was studied on the inhibition of ATP-activated current by extracellularly applied ethanol. Tea made from pine cones is a real treasure of useful substances. More Powerful Immune System Boosters By Using Essential Oils! . Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. Bayer drug suramin is the antidote but it's only available to rich people in Europe. Proceedings of the National Academy of Sciences 83, no. So head over today and like, share and download a few episodes! Various routes to these compounds have been developed, including starting from separate naphthalene structures and building towards an eventual unification by formation of the urea[13][14] or starting with a urea and appending successive groups. It is illegal to import suramin for human use without FDA approval. So there are a few different alternatives. please let me know if you try the two you mentioned at the start of this thread. It also has an, Trypan blue is so-called because it can kill trypanosomes, the parasites that cause sleeping sickness. Though, the other day I did hear someone saying that the bark is even more powerful than the needles so maybe thats something you can follow through on. 1 (1987): 143-148. Wormwood is one of the most effective antiparasitic herbs in the world, and one of the best natural alternatives to Ivermectin. $229.95 New. 17 (1986): 6440-6444. You can obtain enough from pine needle tea (pine, spruce, cedar and fir) . Are there any supplements or lifestyle factors we can utilize to emulate the effects that suramin has? You quoted Rheum Palmatum, but many other plants contain Emodin. I hope this information helps Luke and any others its relevant too. Many dont want to allow their bubble to burst as they feel so safe and secure tucked away inside there. Several P2Y12 inhibitors are approved to treat heart disease, but other purinergic receptors are likely to be more important in ASD. Its not a matter of if, its a matter of when. The differences are about 20% higher. Gourley, P.L. Salgado-Benvindo, C. et al. Today, 100 years later, it is being studied for a variety of applications and treatments . [1] Specifically, it is used for treatment of first-stage African trypanosomiasis caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense without involvement of central nervous system. The most effective dosage solution is the Pine Needle Tincture. Press J to jump to the feed. Suramin was shown to be safe and effective in three preclinical models of ASD9-11 and a small human clinical trial1 in peer-reviewed papers published between 2013-2017. ! Thank you! what about plavix? "Suramin in the treatment of AIDS: mechanism of action." [11], The synthesis of suramin itself and structural analogs is by successive formation of the amide bonds from their corresponding amine (aniline) and carboxyl (as acyl chloride) components. However, it is imperative to choose the right pine needles as there are 20 known toxic varieties of pine trees. Suramin is a 100-year-old drug developed to treat African sleeping sickness and river blindness. Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. No medical research confirms this yet, but people have been using suramin for autism and as a powerful antiviral. Alcohol, well Ethanol, is not a p2x antagonist.