We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying mechanisms. Rationale: The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. 1 für Adressen und Telefonnummern Aims: Zenker Ofenbackform Auflaufform mit Buch Low-Carb-Aufläufe von Wolfgang Link Mit dem 2-teiligen Set mit Ofenbackform und Low-Carb-Aufläufe Buch von Zenker können sie nicht nur tolle Rezepte nachkochen, sondern können auch noch Ihrer Traumfigur ein Stückchen näherkommen. Winda Puspitasari, 2017: Association analyses to genetically study reproduction and seed quality features of faba bean (. Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. 930/931 (9.Stock) Hiroshimaplatz 1-4 37083 Göttingen Telefon 05 51-4 00 23 47 Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. Supplementary Figure Set for Unger et al., Acta Neuropathol Commun. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. Band aus Göttingen. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. However, testing these mechanical hypotheses on native molecules in their natural environment remains inaccessible to conventional genetics, biophysics and molecular biology tools. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. 1984: Dr. rer. agric. Die Aktin- und Myosinfilamente treten durch Bildung bzw. Universitätsmedizin Göttingen Klinik für Neurologie Robert-Koch-Straße 40 37075 Göttingen . Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. In the original version of this article, the name of one of the authors is not correct. Die 25-jährige Studentin engagiert sich in der Gruppierung Basisdemokratische Linke in Göttingen, wo der Schock tief sitzt. With this reproductive behaviour, breeding methods appropriate for faba bean should be general solutions of which the methods for self-fertilizing and cross-fertilizing crops should be just extreme, marginal cases. Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. 34117 Kassel . Crucial role of protein kinase G in regulating Ca2(+)/calmodulin-dependent protein kinase-II activity and oxidative stress: The diastolic function modulation via PKG-dependent CaMKII phosphorylation and oxidation. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0. Current projects: Public relations activity at Reinshof In the Western countries cardiovascular disease and cancer are the leading causes of death in the ageing population. Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. English, German. Here, we report a large, multi-generational family (78 members) with ASD combined with a late-onset dilated cardiomyopathy and further characterize the consequences of mutant α-actin. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. Jede Zelle besitzt ein verzweigtes Netzwerk von... Muskelkraft und -bewegung beruhen auf molekularen Prozessen in den kontraktilen Bausteinen der Muskelzellen, den Sarkomeren. The giant sarcomere protein titin is important in both heart health and disease. We argue that, by comparing tissues from failing human hearts with age-matched non-fail... Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Traditional force spectroscopy of titin can study only eight tandem Ig domains at a time, and the dominant Left ventricular (LV) diastolic dysfunction is among others attributed to cardiomyocyte stiffness. Imbalances in protein homeostasis caused by mutant desmin, 234th ENMC International Workshop: Chaperone dysfunction in muscle disease, December 8-10th 2017, Naarden, Netherlands, A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance. Desmin is the major intermediate filament (IF) protein in human heart and skeletal muscle. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Sehen Sie sich die Profile von Fach- und Führungskräften namens „Wolfgang Link“ auf LinkedIn an. Methods: TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the de... Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). Diese Bewegungen werden durch spezielle Struktur- und Motorproteine in den Muskelzellen ermöglicht. Recent reports suggest that mammalian embryonic coronary endothelium (CoE) develops from the sinus venosus and ventricular endocardium. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Link Wolfgang Dr. Möchten Sie Link Wolfgang Dr. in Göttingen-Groß Ellershausen anrufen? Cuvillier Verlag Göttingen. We investigated newly generated immortalized heterozygous and homozygous R349P desmin knock‐in myoblasts in conjunction with the corresponding desminopathy mice as models for desminopathies to analyse major protein quality control processes in response to the presence of R349P mutant desmin. Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. Accordingly, regulated protein decay is critical to maintain cardiac function. Er leitete von 1977 bis 2014 das Institut für Humangenetik der Medizinischen Fakultät der Universität Göttingen. Join ResearchGate to contact this researcher and connect with your scientific community. Band aus Göttingen. Berufserfahrung, Kontaktdaten, Portfolio und weitere Infos: Erfahr mehr – oder kontaktier Wolfgang H. Geiger direkt bei XING. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. Erstes Album [wolf:gang] 25.08.18 Gregor Welna, 2014: Genetische Analysen für eine markergestützte Verbesserung der Trockenstresstoleranz von Winterackerbohnen. The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. Mesenchymal stromal cells (MSC) have cardiac-protective properties. The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. Die Telefonnummer 0551 9 48 00 finden Sie ganz oben auf der Seite. The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. E-Mail: dialog@vobakg.de . The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxicity. ll Wolfgang Link gesucht? Rudolf-Schwander-Str. SP... Alle tierischen Lebewesen, selbst Einzeller, bewegen sich fort. In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. Briefpostadresse 37099 Göttingen . Mutations in the gene encoding for titin (TTN) are the leading known cause of familial dilated cardiomyopathy. Reminiscent of Myo18b, Myo18a was highly exp... Cardiac functionality is dependent on a balanced protein turnover. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. 234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017. PmtA catalyzes the successive three-step N -... Background: Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Methods: application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and i... Myopathies encompass a wide variety of acquired and hereditary disorders. We used hetero‐ and homozygous R349P desmin... Background Webseiten der Georg-August-Universität Göttingen. Using intravit... Background: We analyzed 2 independent German families with clinical, geneti... Background: Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen Indeed, there is a tight link in terms of shared risk factors and mechanisms... AimsOur aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).Methods Although several studies in non-mammalian vertebrates have proven that extracardiac endothelial cells also participate in CoE development, the contribution of such cells to mammalian CoE is regarded to be minor and... Elucidating the biological mechanisms behind increased myocardial compliance following acute myocardial stretching and their role in cardiac diastolic (dys)function. Universität Göttingen. Kontakt: Telefon: 0551/400-4561 Telefax: 0551/400-4580 E-Mail: w.steinmetzer@goettingen.de Raum: 110 ZUR ÜBERSICHT. Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen To o... Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin prot... Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. International space missions with ESA and NASA. Breeding Research Nursery Objective: E-Mail: neurologie.sekretariat(at)med.uni … Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastructure and mechanics. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Aims Wolfgang Engel (* 18. Max Planck Institute for Solar System Research. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Descriptive terms such as 'HFrEF' (... Titin is a giant elastic protein expressed in the contractile units of striated muscle cells, including the sarcomeres of cardiomyocytes. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Working Group "Breeding Research Faba Bean" Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. November 1940 in Ludwigshafen; † 7. We combined a geno... Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. MPS develops and builds scientific instruments that investigate solar system bodies. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. Friedhof Junkerberg Heinrich-A.-Zachariä-Bogen 12 37077 Göttingen Kontakt: Telefon: 0551/400-5210 Telefax: 0551/400-5222 E-Mail: w.giesse@goettingen.de A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. The relationship between oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle protein titin, which in turn can determine the progression of heart disease. The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Universität Göttingen. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. Wolfgang Victor Ruttkowski is a scholar of literature and culture. Languages. Cuvillier Göttingen (in Zusammenarbeit mit. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. Aims: The heart is constantly challenged with acute bouts of stretching or overload. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. The correct name should be W. A. Linke, which is shown correctly in the authorgroup section above. Leben. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Tel. -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. We therefore investigated the influence of CX3CR1 ablation in the mode... Regulation of chemokine receptors and the corresponding chemokines in the spleen of Coxsackievirus B3-infected mice. Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. However, recent evidence suggests that AVR outcome can be improved if performed earlier. Loop is the open research network that increases the discoverability and impact of researchers and their work. Participation in “Cells in Motion” Research interests: muscle cytoskeletal dynamics, biomolecular and cellular force measurements, atomic force microscopy, cardiomyocyte contractility and elasticity in health and disease, induced pluripotent stem cell-derived cardiomyocytes Papers in the research focus “cell dynamics and imaging” papers by Wolfgang A. Linke Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart, Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator, Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function, A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues, Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D, The Specific Cleavage of Titin Springs to Quantify the Contribution of Titin to Myocardial Passive Stiffness, Erratum: Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis, Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients, Symmetric dimethylarginine in dysfunctional high-density lipoprotein mediates endothelial glycocalyx breakdown in chronic kidney disease, Funktionelle Analyse zweier neuer Desmin-Mutationen, assoziiert mit familiären Kardiomyopathien, Arrhythmien und einem erhöhten Risiko für plötzlichen Herztod, Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function, P.78Sarcomeric pathology induced by homozygous expression of the myofibrillar myopathy - associated p.W2711X filamin C mutant, P.80Imbalances in protein homeostasis caused by mutant desmin, Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis, Abstract 330: A HaloTag-TEV Genetic Cassette for Mechanically Probing Native Titin, Abstract 466: Myopathy Causing Bag3 P209L Protein Leads to Restrictive Cardiomyopathy Caused by Aggregate Formation and Sarcomere Disruption in Cardiomyocytes, Cardiac α-Actin ( ACTC1 ) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy, The Translational Landscape of the Human Heart, Sarkomerische Pathologie durch die homozygote Expression der Myofibrilläre Myopathie-assoziierten W2711X Filamin-C Mutante, Mutiertes Desmin verursacht komplexe Störungen der muskulären Proteinhomeostase, The continuous heart failure spectrum: Moving beyond an ejection fraction classification. : You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells, where it determines passive tension development and modul... Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. Here, we ha... Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. He has written four works of comparative literature and psychology of art, now considered standards of their genre. © 2008-2021 ResearchGate GmbH. Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.A copy of the license is included in the section entitled GNU Free Documentation License. Join ResearchGate to find the people and research you need to help your work. Stadt Göttingen Breslauer Straße 2 37085 Göttingen. Kontakte Fraktion Göttinger Linke . Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. Dahl salt-sensitive (DSS) rats and control rats were fed... Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. This file is licensed under the Creative Commons Attribution 3.0 Unported license. Dort liegen die Eiweiße Myosin und Aktin als Myofilamente vor. entropic effect of the massive native titin polypeptide is lost. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0, Titin phosphorylation by protein kinase G as a novel mechanism of diastolic adaptation to acute load, Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes, The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis, P1582Dietary spermidine ameliorates hypertension and prevents diastolic dysfunction in Dahl salt-sensitive rats, Phenotypic extremes of BICD2-opathies: From lethal, congenital muscular atrophy with arthrogryposis to asymptomatic with subclinical features. nat., University of Göttingen.