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I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. Millions Treated for Hypothyroidism at Risk for Lung Cancer I've been on synthroid for 20+ years, scary. As you know, I appreciate people posting links that help us learn more about lung cancer, too. Angiology 2000, 51:S65S68. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Study: Millions Treated for Hypothyroidism at Risk of Lung Cancer [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. I have been reading Izabella Wentz. It may not display this or other websites correctly. It is very tormenting (for me anyhow) to not know why I got this disease. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. END TIME NEWS, A CALL FOR REPENTANCE, YESHUA THE ONLY WAY TO HEAVEN. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. Metab.87 (2): 48999. The Remarkable Heart-Friendy Properties of Avocados. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer at As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called 'active ingredient' T4 versus the natural variations in hormone concentrations found in the 'real thing,' which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Keep checking back for the register link to appear. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). PLoSone 2011, 11:e27547. As I have lung cancer and just recently was diagnosed hypothyroidI am very interested as to what you have to say about this connection.your personal insight and any books, websites would be appreciated.you may email me if you prefer. Subclinical hypothyroidism: When to treat | Cleveland Clinic Journal of Symptoms. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. Why not simply call it selenium deficiency? millions treated for hypothyroidism at risk for lung cancer Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. This discussion has been closed to comments. A distorted idea of human nature is sold when people are treated as "the market. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. Hypothyroidism - StatPearls - NCBI Bookshelf Log In. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. Researchers are currently studying. Join the Patient & Caregiver Network. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study video where the doc is talking about the study , i wlll link study and video below. Another recently approved drug is tepotinib (Tepmetko). A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. 2013 May ;98(5):1982-90. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. florence nightingale concept 2 via de boleto The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. ", That study is like a fishing expedition. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Untreated hypothyroidism increases morbidity and mortality. Correlation is not causation. Hypothyroidism can also lead to swelling of the tongue, hoarse voice, and sleep apnea. Endocrinology 1985, 117:12011208. PMID: 15253676. Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. Dr Childs guesses that patients on levothyroxine monotherapy may be more prone to cancer because they might be under-treated. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to 'replacement' therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. Nah, I would give this much credence. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. I very much appreciate the information you shared. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . Overtreatment, of course, is the hallmark danger of overdiagnosis. Hypothyroidism (underactive thyroid) - Diagnosis and treatment - Mayo I can understand why tennis 123 wrote, "I have so much to say about this I could write a book". [14] K A Woeber. However, I do not believe it was out of the blue now. Capmatinib (Tabrecta) is the first FDA-approved MET-targeting medication for treating metastatic NSCLC. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. May be of interest: Study: Millions Treated for Hypothyroidism At Risk A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related diseases..